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KMID : 0032220060180020091
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Annals of Dermatology
2006 Volume.18 No. 2 p.91 ~ p.96
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A Case of Secondary Cutaneous Diffuse Large B-Cell Lymphoma
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Kim Jung-Keun
Kim Tack-Hun
Park Tae-Ho
Yoo Jae-Hak
Kim Kea-Jeung
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Abstract
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We report here on a case of secondary cutaneous diffuse large B-cell lymphoma (DLBCL) that occurred in a 67-year-old man who had a 2-month history of nodular growing masses on the left cheek, plus palpable lymph nodes on the left cervical area. The histopathological findings showed a diffuse infiltration of large atypical lymphocytes with nuclear atypia throughout the entire dermis. These showed positive CD20, bcl-2 and the post-germinal center marker, MUM-1. According to the WHO (World Health Organization) classification, this lymphoma is considered to be diffuse large B-cell lymphoma of the post-germinal center (GC) B-cell type with a secondary cutaneous manifestation. We treated the patient with systemic chemotherapy (CHOP) and anti-CD20 monoclonal antibodies. During the course of treatment, new skin lesions developed on his neck, so we changed the regimen to cytosin- arabinoside and cisplatin. But he died of pneumonia after the third cycle.
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KEYWORD
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Bcl-2, Post-GC B-cell, Secondary cutaneous diffuse Large B-cell Lymphoma
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